Figure 3.

Galectin-3 is upregulated in multiple sclerosis and controls angiogenesis after stroke. (A) Gal-3 immunohistochemistry (brown) in human brain sections shows that compared to a healthy control, Gal-3 is increased near the lateral ventricle (LV) in an MS patient. (Adapted from [50]. (B) Gal-3 immunofluorescence (green) is increased in the striatum and cerebral cortex of a mouse middle cerebral artery occlusion (MCAO) stroke model. (C) Quantification of B showing significantly increased Gal-3 at days 3 and 7 post-stroke. (D) Platelet endothelial cell adhesion molecule (PECAM) blood vessel immunofluorescence (red) in the striatum of WT and Gal-3^−/− mice, with or without MCAO. (E) Quantification of D showing increased blood vessels after MCAO in controls but not in Gal-3^−/− mice. ((B–E) Adapted from [10]), with permission. * p < 0.05, *** p < 0.001.