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Synthesis of multifunctional mesoporous silica nanoparticles (SBA-15). Step 1: installation of APTMEES at room temperature, Step 2: conjugation of eosin isothiocyanate (EOITC) fluorescent dye, Step 3: conjugation of 99mTc/188Re chelator, Step 4: radiolabeling with 99mTc or 188Re [55].
