Table 3.

Summary of ^99mTc-labeled organic nanoparticles and their applications.

Nanoparticle	Application	Drug Loaded on NPs	Radiolabeling Method	Ref.
Dendrimer	Human breast cancer (MCF-7) imaging	Without drug	Chelator-based radiolabeling using HYNIC and stannous chloride (reducing agent)	[58]
	A549 tumor imaging	Without drug	Direct radiolabeling using stannous chloride (reducing agent)	[59]
Polymeric Nanoparticles	General biodistribution study	Etoposide	Direct radiolabeling using stannous chloride (reducing agent)	[60]
	Sentinel lymph node	Without drug	Direct radiolabeling using stannous chloride (reducing agent),chelator-based radiolabeling using DTPA	[61]
	Comparative study using various reducing agents for 99mTc radiolabeling	Without drug	Direct radiolabeling using stannous chloride, sodium dithionite or sodium borohydride (reducing agent)	[62]
	Imaging of folate receptor overexpressed tumors	Folic acid	Direct radiolabeling using stannous chloride (reducing agent)	[63]
	Imaging of folate receptor or vascular endothelial growth factor receptor-2 (VEGFR-2) overexpressed tumors	Folic acid (FA) to target folate receptor and K237 (HTMYYHHYQHHL) peptide	Direct radiolabeling using stannous chloride (reducing agent)	[64]
	General biodistribution study	Gemcitabine	Direct radiolabeling using tricarbonyl kit	[65]
Lipid nanoparticles	Imaging of folate receptor overexpressed tumors	Cisplatin and folic acid	Direct radiolabeling using stannous chloride (reducing agent)	[68]
	Bone imaging	Methylene diphosphonate (MDP)	Direct radiolabeling using stannous chloride (reducing agent)	[69]
Liposomes nanoparticles	General biodistribution study	Without drug	Direct radiolabeling on the surface of nanoparticles	[71]
	General biodistribution study	Without drug	Chelator-based radiolabeling using 2-Iminothiolane and tricrbonyl kit	[72]
Oligomers	Human HepG2 cells targeting	Folic acid	Direct radiolabeling using stannous chloride (reducing agent)	[74]
Protein nanoparticles (Human Serum Albumin)	General biodistribution study	Bevacizumab	Direct radiolabeling using tricarbonyl kit	[77]
	General biodistribution study	HPMC, GMN2, GPM2 and GTM2 polymer coating	Direct radiolabeling using stannous chloride (reducing agent)	[78]