Table 1.
Neuropsychiatric Studies Investigating NLRP3 Inflammasome Activation in Mood Disorders. Seven articles [24,25,26,27,28,29,30] investigated NLRP3 inflammasome activation in patients suffering from bipolar disorder and major depressive disorder. All studies use PCR, assay ELISA, or Western blotting to measure mRNA and protein expression in human blood samples containing either PBMC, serum, or plasma.
| Reference | Number of Patients | Sample | Assays | ||
|---|---|---|---|---|---|
| Healthy | BD/MDD | Medicated | |||
| Alcocer-Gómez et al., (2014) | 20 | 20 | 20 | PBMC, Serum | PCR, ELISA, Western Blot |
| Momeni et al., (2016) | 43 | 38 | PBMC | PCR | |
| Alcocer-Gómez et al., (2017) | 20 | 20 | 194 | PBMC, Serum | PCR, ELISA |
| García-Álvarez et al., (2018) | 80 | 102 | PBMC, Plasma | Western Blot | |
| Scaini et al., (2018) | 25 | 31 | PBMC | PCR, Western Blot | |
| Taene et al., (2020) | 20 | 20 | 20 | PBMC, Serum | PCR |
| Li et al., (2021) | 24 | 24 | Serum | PCR, ELISA | |