Table 2.
Protein and Gene Expression Levels of the NLRP3 Inflammasome in Mood Disorder Studies. No studies measured ASC protein levels. * Denotes one study which demonstrated decreased levels of the NLRP3 inflammasome specifically in MDD patients taking medication [26].
| Reference | NLRP3 | ASC | Caspase-1 | IL-1 beta | IL-18 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| mRNA | Protein | mRNA | Protein | mRNA | Protein | mRNA | Protein | mRNA | Protein | |
| Alcocer-Gómez et al., (2014) | Increase | Increase | Increase | Increase | Increase | |||||
| Momeni et al., (2016) | Increase | |||||||||
| Alcocer-Gómez et al., (2017) | Increase * | Increase | Increase | |||||||
| García-Álvarez et al., (2018) | Increase | |||||||||
| Scaini et al., (2018) | Increase | Increase | Increase | Increase | Increase | |||||
| Taene et al., (2020) | Increase | Increase | ||||||||
| Li et al., (2021) | Increase | Increase | Increase | Increase | Increase | |||||