Figure 4.

The effect of repeated doses of 10-fold diluted mometasone and placebo nasal spray, culture medium or intact condition on the ciliary beat frequency (CBF) of the nasal MucilAir™ in vitro model. Results are presented as relative CBF values, expressed as a percentage of the CBF values relative to the corresponding baseline control condition for each tested group measured before treatments. The red dotted line represents 100% (the value of the control condition before treatment). Each bar represents average relative CBF ± S.E. Diluted mometasone and placebo nasal spray do not inhibit CBF compared to the culture medium-treated and intact nasal in vitro models. Culture medium treatment increases CBF in the second week of daily treatments. n = 50, two-way ANOVA with Tukey’s multiple comparisons test; * p < 0.05, *** p < 0.001.