Figure 3.

Paracrine influence on dermal healing and maturation. (A) Aged day 14 CM from both the groups exerted similar levels of wound closure activity in human adult dermal fibroblasts by approximately 40% in 12 h. (B) CM from the gene-activated scaffold significantly reduced the expression of pro-fibrotic collagen I in the fibroblasts. * indicates p < 0.05. Data represents mean ± standard deviation (n = 3). In Figure 3B, GAS and GFS stand for gene-activated scaffold and gene-free scaffold respectively.