Figure 5.

A schematic of the functional impact of β-Klotho gene-activated scaffold on human ADSCs for wound healing applications. The key findings of this study are the (1) transient enhancement of stem cell pluripotency and anti-fibrotic response, (2) improved paracrine control towards angiogenesis, and pro-fibrotic collagen remodeling in dermal fibroblasts, and ultimately, (3) increased maturation of the basement membrane with control over scar-associated proteins’ expression. Dotted lines for elastin matrix imply improved qualitative deposition.