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CKO mice have reduced corticosterone levels after restraint stress and in DEX/CRH testing. (A,B) Corticosterone concentration in basal (A) and restraint stressed conditions (B) in WT (n = 7) and CKO (n = 7) mice. (C,D) DEX/CRH test. The corticosterone level after DEX treatment (C) and then CRH challenge (D) in WT (n = 13) and CKO (n = 14) mice. Results are presented as means ± SD, ** p ≤ 0.01, compared with the WT group.
