Changes in the expression patterns of key genes relevant to the regulation of HPA axis in hypothalamus and pituitary gland tissues. (A) Crabp1 protein levels in the hippocampus (HP), hypothalamus gland (HT), pituitary gland (PG), and adrenal gland (AG). (C,D) Changes in gene expression in the hypothalamus gland (B,D) and pituitary gland (C,E) of WT (n = 6) and CKO (n = 6) mice. (F,G) FKBP5 protein levels in the hypothalamus gland of WT (n = 3) and CKO (n = 3) mice. β-actin was used as a loading control. Western blot quantification shown in (G). Results are presented as means ± SD, * p ≤ 0.05, ** p ≤ 0.01, compared with WT group.