Table 2.

The summary of data extracted from eligible articles. Abbreviations: Wt (Wildtype), AMP (Adenosine Monophosphate), IMP (Inosine monophosphate), GMP (Guanosine monophosphate), CMP (Cytidine monophosphate), UMP (uridine monophosphate) (>) indicates high levels of metabolites seen in one group in contrast to the other. (<) indicates, low levels of metabolites observed in one group in comparison to the other. (=) indicates comparable levels of metabolites demonstrated in both groups.

Reference	Metabolite of Interest	Notable Findings
[48]	5′AMP, 5′IMP, 5′GMP, 5′CMP, 5′UMP, adenosine, inosine, guanosine, uridine, cytidine, adenine, hypoxanthine, guanine, xanthine, uracil, cytosine, sedoheptulose-7-phosphate (S7P), sedoheptulose-1,7-bisphosphate (SBP)	Carbon Starvation Nucleosides, nucleobases (ratio of metabolite levels in deleted/Wt strain) Wt > atg7Δ (steady increase in inosine, guanosine, uridine, cytidine, hypoxanthine, guanine, xanthine, uracil levels in Wildtype than atg7Δ) Wt > bcyΔ (steady increase in adenosine, inosine, guanosine, uridine, cytidine, hypoxanthine, guanine, xanthine, uracil levels in Wildtype than atg7Δ) Wt > snfΔ (steady increase in adenosine, inosine, guanosine, uridine, cytidine, hypoxanthine, guanine, xanthine, uracil levels in Wildtype than atg7Δ) Wt > pnp1Δ (steady increase in hypoxanthine, guanine, xanthine, and uracil levels in Wildtype than pnp1Δ) Wt > urh1Δ (steady increase in hypoxanthine, guanine, xanthine, and uracil in Wildtype than urh1Δ Ribose-5-Phosphate and Sedoheptulose-7-phosphate (S7P) and Sedoheptulose-1,7-bisphosphate (SBP) species (ratio of metabolite levels in deleted/Wt strain) Wt > atg7Δ (steady increase in R5P, S7P and SBP in Wildtype than atg7Δ) Wt > bcyΔ (steady increase in R5P, S7P and SBP in Wildtype than atg7Δ) Wt > snfΔ (steady increase in S7P and SBP in Wildtype than atg7Δ, transient increase in R5P levels in Wildtype than atg7Δ) Wt > pnp1Δ (steady increase in R5P, S7P, SBP in Wildtype than pnp1Δ) Wt > urh1Δ (steady increase R5P, S7P, SBP in Wildtype than urh1Δ) Sedoheptulose-7-phosphate (S7P) and Sedoheptulose-1,7-bisphosphate (SBP) species (Intracellular concentration (uM)) Wt > tkl1Δ/tkl2Δ (steady increase in S7P and SBP in Wildtype than tkl1Δ/tkl2Δ strain) Nitrogen Starvation: Nucleosides, nucleobases sedoheptulose species (ratio of metabolite levels in deleted/Wt strain) Wt > atg7Δ (transient increase in inosine, guanosine, uridine, cytidine, hypoxanthine, guanine and uracil levels in Wildtype than atg7Δ) Wt = atg7Δ (comparable levels of adenosine and guanine between the two groups) Phosphate Starvation Nucleosides, nucleobases (ratio of metabolite levels in deleted/Wt strain) Wt = atg7Δ (comparable levels of adenosine, inosine, guanosine, uridine, cytidine, hypoxanthine, guanine, xanthine and uracil between the two groups)
[49]	5′AMP, 5′GMP, 5′CMP, 5′UMP, 3′AMP, 3′GMP, 3′UMP, Adenosine, Guanosine, Cytidine, Uridine, inosine, adenine, hypoxanthine, guanine, xanthine, uracil.	Carbon Starvation Nucleosides: adenosine, guanosine, cytidine, uridine (relative intensity) Wt > atg2Δ (high levels of nucleosides (except for adenosine) in Wildtype than atg2Δ) Nitrogen Starvation Intracellular Nucleosides: adenosine, guanosine, cytidine, uridine (µM) Wt > atg2Δ (transient increase in adenosine, guanosine, cytidine levels in Wildtype than atg2Δ) Wt > atg2Δ (steady increase in inosine and uridine in Wildtype than atg2Δ) Intracellular Nucleobases: adenine, hypoxanthine, guanine, xanthine, uracil (µM) Wt > atg2Δ (transient increase in adenosine, guanosine, cytidine levels in Wildtype than atg2Δ) Wt > atg2Δ (steady increase in inosine and uridine in Wildtype than atg2Δ) Extracellular Nucleosides: inosine, guanosine, cytidine, uridine (µM) Wt > atg2Δ (steady increase in inosine, guanosine, cytidine, and uridine in Wildtype than atg2Δ) Extracellular Nucleobases: xanthine, uracil (µM) Wt > atg2Δ (steady increase in xanthine and uracil in Wildtype than atg2Δ) Relative intensity levels of 3′AMP, 3′GMP, 3′UMP Wt > atg2Δ (Diminished levels of 3′AMP, 3′GMP and 3′UMP in atg2Δ strain than in Wildtype) Wt > rny1Δ (Diminished levels of 3′AMP, 3′GMP and 3′UMP in atg2Δ strain than in Wildtype) Relative intensity (Nucleosides and nucleobases) levels of guanosine, inosine, guanine, xanthine, cytidine, uridine, uracil Wt > atg2Δ (high levels of guanosine, inosine, guanine, xanthine, cytidine, uridine, uracil in Wildtype than atg2Δ) Wt < pnp1Δ (high levels of guanosine, inosine, cytidine, and uridine in pnp1Δ strain than in Wildtype) Wt = pnp1Δ (comparable levels of xanthine, guanine and uracil in pnp1Δ strain than in Wildtype) Wt < urh1Δ (high levels of cytidine and uridine in urh1Δ strain than in Wildtype) Wt < urh1Δ (high levels of uracil in Wildtype than in urh1Δ) Wt > atg7Δ & atg17Δ (high levels of adenosine, guanosine, cytidine, uridine in Wildtype than in atg7Δ & atg17Δ) Wt = atg19Δ, atg32Δ, NVJ1Δ, atg11Δ (comparable levels of adenosine, guanosine, cytidine and uridine)
[32]	Exploratory (Untargeted)	Glucose Starvation ATP, Glucose-6-phosphate (G6P), Ribose-5-phosphate (R5P), glutamate, sedoheptulose-7-guanine, phosphoenolpyruvate UDP-hexose Wt > cbp2Δ (High levels of ATP, Glucose-6-phosphate (G6P), Ribose-5-phosphate (R5P), glutamate, sedoheptulose-7-guanine, phosphoenolpyruvate UDP-hexose in Wildtype than in cbp2Δ Aspartate and glutamate Wt > cbp2Δ (High levels of aspartate and glutamate in Wildtype than in cbp2Δ) Acute Glucose Starvation: Hexose, Hexose-Phosphate, Pentose, NADH (sub-minute levels) Non-Starved Wt > Starved Wt (High levels of pentose phosphate, ribose phosphates and pentose in non-starved Wildtype than starved Wildtype) Acute Glucose Starvation: ATP, AMP (sub-minute) Non-Starved Wt > starved Wt cells (ATP) Starved Wt > non-starved Wt cells (AMP) Lipid Profiling Polyketides, Dolichols Starved Wt > non-starved Wt cells (High levels of Polyketides dan Dolichols in starved Wildtype than non-starved %ATP Wt = atg14Δ Wt > pot1Δ Wt > atg2Δ Wt > atg2Δpot1Δ
[14]	Arginine, histidine, proline, methionine, isoleucine, (ratio of leucine/isoleucine), valine, serine, (ratio of threonine/histidine) phenylalanine, tyrosine, tryptophan, glutamine, glutamate, asparagine, aspartate, fructose-bisphosphate (FBP), 2/3-phosphoglycerate (2/3-PG), pyruvate, citrate, alpha-ketoglutarate (a-KG), succinate, fumarate, malate	Nitrogen starvation Amino acids, intermediates of glycolysis, and tricarboxylic acid (TCA) cycle (intracellular concentration (uM)) Wt = atg1Δ (comparable levels, however, aspartate, glutamate, glutamine, valine, and alpha-ketoglutarate were found to be slightly higher abundance in Wt than atg1Δ) Aspartate and Glutamate (relative abundance) Wt > atg1Δ, atg6Δ, atg9Δ, atg15Δ, ypt7Δ, pep4prb1Δ Wt = atg19Δ, atg32Δ, NVJ1Δ Wt > gdh1Δgdh3Δglt1Δ > atg1Δ (triple deletion reduces Glu and Asp by 50%) Wt > glt1Δ > atg1Δ Wt > aat2Δ (aspartate levels completely abolished)