Table 2.
Risk factors for severe disease.
| Mild/Moderate Disease (n = 164) | Severe Disease (n = 46) | Univariate Odds Ratio (95% CI) |
p-Value | Multivariate Odds Ratio (95% CI) |
p-Value | |
|---|---|---|---|---|---|---|
|
Age in years
Mean (SD) |
51.2 (18.13) | 51.3 (18.81) | 1.00 (0.98–1.02) | 0.960 | ||
| Male Sex | 70.1 (115/164) | 73.9 (34/46) | 1.21 (0.58–2.53) | 0.617 | ||
| Race | ||||||
| White | 91.3 (136/149) | 86.1 (37/43) | Reference | |||
| Black | 3.4 (5/149) | 7.0 (3/43) | 2.21 (0.50–9.66) | 0.294 | ||
| Asian | 4.7 (7/149) | 2.3 (1/43) | 0.53 (0.06–4.40) | 0.553 | ||
| American Indian | 0.7 (1/149) | 4.7 (2/43) | 7.35 (0.65–83.32) | 0.107 | ||
| Hispanic | 3.7 (5/135) | 0 | - | |||
| Asthma/COPD | 9.8 (16/164) | 6.5 (3/46) | 0.65 (0.18–2.32) | 0.502 | ||
| Diabetes mellitus | ||||||
| All | 23.2 (38/164) | 21.7 (10/46) | 0.92 (0.42–2.03) | 0.838 | ||
| Insulin-Dependent | 7.9 (13/164) | 13.0 (6/46) | 1.74 (0.62–4.87) | 0.290 | ||
| Renal Failure | 5.4 (8/149) | 15.6 (7/45) | 3.25 (1.11–9.52) | 0.032 | 2.43 (0.79–7.46) | 0.119 |
| Obesity | 31.5 (47/149) | 41.9 (18/43) | 1.56 (0.78–3.14) | 0.210 | ||
| Extrapulmonary Disease | 26.2 (43/164) | 19.6 (9/46) | 0.68 (0.31–1.53) | 0.357 | ||
| Corticosteroid Treatment | 7.9 (13/164) | 4.4 (2/46) | 0.53 (0.11–2.43) | 0.412 | ||
| Pharmacologic Immunosuppression | 19.5 (32/164) | 15.2 (7/46) | 0.74 (0.30–1.81) | 0.509 | ||
| Solid Organ Transplant | 6.7 (11/164) | 10.9 (5/46) | 1.70 (0.56–5.16) | 0.352 | ||
| Neutrophilia 1 | 43.1 (59/137) | 72.7 (32/44) | 3.52 (1.67–7.42) | 0.001 | 3.35 (1.53–7.35) | 0.002 |
| Lymphopenia 2 | 27.7 (38/137) | 59.1 (26/44) | 3.76 (1.85–7.64) | <0.001 | 3.34 (1.59–7.03) | 0.001 |
Data are presented as percentages (absolute numbers shown in parentheses), unless otherwise indicated. CI, confidence interval; COPD, chronic obstructive pulmonary disease. 1 Neutrophil count ≥ 7.5 × 103cells/microL. 2 Lymphocyte count < 1.0 × 103 cells/microL.