Table 5.
Sensitivity of diagnostic assays in patients with disease confirmed by culture and/or histopathology with comparison between pulmonary and extrapulmonary disease.
| All | Pulmonary Disease | Extrapulmonary Disease | p-Value * | |
|---|---|---|---|---|
| Blastomyces EIA | 52.1 | 47.3 | 68.8 | 0.13 |
| (40.7–63.3) | (34.7–60.2) | (44.4–85.8) | ||
| 37/71 | 26/55 | 11/16 | ||
| Blastomyces Immunodiffusion | 39.6 | 36.1 | 52.6 | 0.19 |
| (30.1–49.8) | (26.0–47.7) | (31.7–72.7) | ||
| 36/91 | 26/72 | 10/19 | ||
| Blastomyces Complement Fixation | 22.9 | 17.9 | 42.9 | 0.31 |
| (12.1–39.0) | (7.9–35.6) | (15.8–75.0) | ||
| 8/35 | 5/28 | 3/7 | ||
| Urine Blastomyces Antigen | 80.8 | 87.8 | 54.6 | 0.03 |
| (68.1–89.2) | (74.5–94.7) | (28.0–78.7) | ||
| 42/52 | 36/41 | 6/11 | ||
| Serum Blastomyces Antigen | 64.3 | 66.7 | 60.0 | 1.00 |
| (38.8–83.7) | (35.4–87.9) | (23.1–88.2) | ||
| 9/14 | 6/9 | 3/5 | ||
| Histoplasma Complement Fixation | 17.9 | 17.9 | None | - |
| (7.9–35.6) | (7.9–35.6) | |||
| 5/28 | 5/28 | |||
| Histoplasma Immunodiffusion | 0/7 | 0/7 | None | - |
| Urine Histoplasma Antigen | 58.8 | 58.6 | 60.0 | 1.00 |
| (42.2–73.6) | (40.7–74.5) | (23.1–88.2) | ||
| 20/34 | 17/29 | 3/5 |
EIA: enzyme immunoassay, BAL: bronchoalveolar lavage. * Comparison between sputum and lower respiratory tract specimens (tracheal secretions, bronchial washings, bronchoalveolar lavage fluid).