Figure 6.

Effect of acute stress application on whole-body cortisol concentrations of one-year-old adult zebrafish, as depicted by bar graphs. Measurements of 10 hsd11b2^+/+ (A) WT and 10 hsd11b2^−/− (B) mutant zebrafish prior to (control) at 15 min, 30 min, 60 min and 120 min after the stress application. Values are means ± SEM. Means with different letters differ significantly from one another (p < 0.001). Asterisks show statistically significant differences between the two groups (p < 0.001). Holm-Sidak comparison test was applied to identify groups that were significantly different. * p < 0.05, ** p < 0.01.