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. 2021 Nov 19;22(22):12483. doi: 10.3390/ijms222212483

Figure 3.

Figure 3

The changes of DNMT1 levels in the astrocytes of ischemic penumbra at 4 and 24 h after photothrombotic stroke (PTS) in the rat cerebral cortex. The levels of DNMT1 at 4 and 24 h after PTS are shown (PTS4 and PTS24, respectively) compared to the contralateral cortex of the same animals (CL4 and CL24), or the cortex of sham-operated rats (SO). (a) Immunofluorescence of DNMT1 (green), marker of astrocytes GFAP (red), nuclear chromatin marker Hoechst 33342 (blue), and image overlay. The scale bar is 50 μm. (b) Coefficient M1 of DNMT1 co-localization with astrocyte marker (GFAP) in different control and experimental groups. * p < 0.05 compared to SO, # p < 0.05 compared to CL4 and CL24. One Way ANOVA; M ± SEM; n = 7.