Table 2.
Anticancer activity of peptides in cell monolayers and spheroids.
| Peptide | IC50 Values [μM] | |||||
|---|---|---|---|---|---|---|
| TNBC Cells | HER2+ Cells | |||||
| MDA-MB-231 | BT-20 | BT-474 | ||||
| Monolayer * | Spheroid # | Monolayer * | Spheroid # | Monolayer * | Spheroid # | |
| PepH3 | >100 | >100 | >100 | >100 | >100 | >100 |
| vCPP2319 | 4.5 ± 0.07 | 22.1 ± 3.67 | 4.2 ± 2.22 | 21.3 ± 2.98 | 15.7 ± 1.46 | 47.9 ± 3.97 |
IC50 is the concentration causing 50% death of cells. HER2, Human epidermal growth factor receptor-2; TNBC, Triple-negative breast cancer; *, results upon 24-h incubation; #, results upon 5-day incubation.