Table 1.
Mutation sites in the QRDRs of gyrA, gyrB, parC, and parE genes of S. Enteritidis mutants.
| Strain Number | MIC (μg/mL) | Substitutions in QRDR Amino Acid Residues | |||
|---|---|---|---|---|---|
| gyrA | gyrB | parC | parE | ||
| 2M (1/2M) | 0.125 | wt | wt | wt | wt |
| 2M (1/8M) | 0.125 | Asp87Gly | wt | wt | wt |
| 2M (1/32M) | 0.125 | wt | wt | wt | wt |
| 2M (1/128M) | 0.125 | Ser83Tyr | wt | wt | wt |
| 4M (1/2M) | 0.25 | wt | wt | wt | wt |
| 4M (1/8M) | 0.25 | Ser83Phe | wt | wt | wt |
| 4M (1/32M) | 0.25 | Ser83Tyr | wt | wt | wt |
| 4M (1/128M) | 0.25 | Ser83Tyr | wt | wt | wt |
| 8M (1/2M) | 0.5 | wt | wt | wt | wt |
| 8M (1/8M) | 0.5 | Ser83Phe | wt | wt | wt |
| 8M (1/32M) | 0.5 | Ser83Phe | wt | wt | wt |
| 8M (1/128M) | 0.5 | Asp87Gly | wt | wt | wt |
| 16M (1/2M) | 1 | Ser83Phe | wt | wt | wt |
| 16M (1/8M) | 1 | Ser83Phe | wt | wt | wt |
| 16M (1/32M) | 1 | Ser83Tyr | wt | wt | wt |
| 32M (1/2M) | 2 | Ser83Tyr | wt | wt | wt |
Note: “wt” represented no mutation was observed.