Table 2.

List of sites in spike protein that are under positive selection or significantly variable, which map to substitutions sampled in VoC/VoI. Highly variable sites are shown as grey filled rows.

Codon	Observed Substitutions	Substitution Attributed to VoC/VoI
19	I, R	T19R (Delta)
20	A, I, N	T20N (Gamma)
26	H, L, S	P26S (Gamma)
69	S, Y, -	H69- (Alpha, Eta)
80	A, G, H, N, Y	D80A (Beta)
95	I, S	T95I (Delta, Kappa)
138	H, Y	D138Y (Gamma)
142	D, S, -	G142D (Delta, Kappa)
154	K	E154K (Kappa)
157	S, L, -	F157- (Delta), F157S (Alpha)
215	G, H, Y	D215G (Beta)
222	S, V	A222V (Delta)
417	N, T	K417N (Beta), K417T (Gamma)
452	M, Q, R	L452R (Delta, Kappa)
478	I, K	T478K (Delta)
484	D, K, Q	E484K (Alpha)
501	S, T, Y	N501Y (Alpha, Beta, Gamma)
570	D, S, V	A570D (Alpha)
681	H, L, R	P681H (Alpha), P681R (Delta and Kappa)
701	T, V, S	A701V (Beta)
716	I	T716I (Alpha)
950	H, N	D950N (Delta)
982	A	S982A (Alpha)
1071	E, H, L	Q1071H (Kappa)
1118	H, Y	D1118H (Alpha)
1191	N	K1191N (Alpha)