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. 2021 Nov 18;26(22):6965. doi: 10.3390/molecules26226965

Table 1.

Proteasomal activity and the level of 20S proteasome in breast and ovarian cancer tissues.

Biological Sample Enzymatic Activity, 103 U/mg Protein Level of the 20S Proteasome (α + β), RU
ChTL CL
Breast tissues (all subtypes), T1–2N0–1M0
Cancer tissues,
n = 80
45.6 [19.8; 92.3] * 53.4 [18.4; 197.2] * 0.72 [0.3; 2.5]
Adjacent tissues,
n = 80
19.8 [10.3; 42.1] 17.7 [8.3; 43.6] 1.0 [0.3; 3.1]
Ovarian tissues, T3NxM0
Cancer tissues,
n = 30
30.0 [26.0; 45.2] ** 57.3 [13.6; 127.4] ** 1.7 [0.8; 2.9] **
Normal tissues,
n = 10
13.0 [7.8; 15.6] 21.3 [11.2; 51.4] 1.0 [0.5; 2.0]

Note: Median and range value [25; 75%], RU–related units. * Significant differences with adjacent breast tissue, p < 0.05; ** Significant differences with normal ovarian tissue, p < 0.05.