Table 3.
Studies included in the meta-analysis of the association between serum BDNF levels and brain volume measurements
| Author [citation] | Sample size | Mean age in years (SD) | Gender (M:F) | Country | Mean years of education (SD) | BDNF source | Assay method | MRI technique | Region(s) measured | Correlation with BDNF (r) |
|---|---|---|---|---|---|---|---|---|---|---|
| Zugman et al. [49] | 29 | 32.17 (11.43) | 21:8 | Spain | 10.84 (3.4) | Serum | Sandwich-ELISA | Scanner: 1.5-T imaging system Acquisition: 3D SPGR sagittal T1 sequence ROI selection/measurement: FreeSurfer software, automated segmentation | Right and left hippocampus; right and left amygdala; total cortical volume | −0.104, 0.03 −0.40, −0.18 −0.522 |
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| Rizos et al. [50] | 20 | 30.75 (10.59) | 8:12 | Greece | 11.15 (2.92) | Serum | Quantikine Immunoassay | Scanner: 1.5-T imaging system Acquisition: dual echo axial/sagittal T1 sequence ROI selection/measurement: manual segmentation, V1L2, pixel-based volumetry | Right hippocampus | 0.452 |
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| Rizos et al. [51] | 14 | 29.71 (10.21) | 8:6 | Greece | 13.00 (3.65) | Serum | Quantikine Immunoassay | Scanner: 1.5-T imaging system Acquisition: dual echo axial/sagittal T1 sequence ROI selection/measurement: manual segmentation, V1L2, pixel-based volumetry | Right and left hippocampus | 0.281, 0.597 |
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| Song et al. [52] | 46 | 2.54 (5.79) | 28:18 | China | 12.63 (2.09) | Serum | ELISA | Scanner: 3.0-T imaging system Acquisition: T1-weighted spoiled gradient echo (SPGR) ROI selection/measurement: FreeSurfer software, automatic parcellation | Right and left hippocampus | 0.338, 0.327 |
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| Song et al. [53] | 45 | 22.09 (4.95) | 27:18 | China | 12.53 (2.18) | Serum | ELISA | Scanner: 3.0-T imaging system Acquisition: T1-weighted spoiled gradient echo (SPGR) ROI selection/measurement: FreeSurfer software, automatic parcellation | Left insula | 0.035 |
BDNF, brain-derived neurotrophic factor; ROI, region-of-interest.