Table 1.
Effects of the Hb concentration on the size, polydispersity (PDI), loading content (LC), entrapment efficiency (EE), and functionality of the resulting HbNPs 1.
| Sample ID | Hb (mg mL−1) |
Size (nm) | PDI | LC (%) | EE (%) | Functional |
|---|---|---|---|---|---|---|
| PLGA-NPs | 0 | 269.1 | 0.074 | - | - | - |
| HbNPs-1 | 5 | 262.5 | 0.064 | - | - | - |
| HbNPs-2 | 10 | 273.8 | 0.093 | - | - | No |
| HbNPs-3 | 25 | 255.1 | 0.060 | 1.8 | 42.8 | No |
| HbNPs-4 | 50 | 277.7 | 0.082 | 9.0 | 30.1 | No |
| HbNPs-5 | 75 | 313.9 | 0.156 | 14.9 | 32.6 | No |
| HbNPs-6 | 100 | 346.7 | 0.144 | 20.6 | 33.8 | Semi |
1 The HbNPs were prepared using 12.5 mg mL−1 PLGA and 1% PVA.