Table 1.

Summary of the characteristics of the included studies

Author	Study location	Study design	Eyes, n		Mean age, years		Gender (male/female)		Minimum diameter		Hole closure rate, %		Follow-up, months
			ILM flap	ILM peeling	ILM flap	ILM peeling	ILM flap	ILM peeling	ILM flap	ILM peeling	ILM flap	ILM peeling
Kannan et al. [14]	India	RCT	30	30	59.37	61.17	11/19	17/13	803.33	759.97	90	76.7	6
Iovino et al. [16]	Italy	RCT	20	20	71	69	9/11	7/13	666.95	664.6	100	100	6
Manasa et al. [11]	India	RCT	43	48	63.41	60.95	20/23	22/26	673	657.5	95.3	87.5	3
Velez-Montoya et al. [15]	Mexico	RCT	12	12	64.2	61.8	nr	nr	608.89	522.22	91.67	91.67	3
Michalewska et al. [10]	Poland	RCT	50	51	66	65	13/33	8/32	759	698	98	88	12

RCT, randomized controlled trial; ILM, internal limiting membrane; nr, not reported.