Table 5.

Comparison of Different Doses of Naringin and Its Derivatives in Cardiovascular Diseases

Compound Name	Experimental Model and Dose	Mechanism	Pharmacological Effect	References
Naringin	High-fat diet-induced rat model (100 mg/kg body weight)	Ameliorated functioning of endothelium by enhancing bioavailability of NO (nitric oxide) Moreover, exert therapeutic effects against prolonged inflammation by decreasing levels of inflammatory mediators intracellularly	Decrease blood pressure and treat hypertension	[4]
	Stroke-prone hypertensive Wistar rats (200, 500, and 1,000 mg/kg)	Ameliorated functioning of endothelium by enhancing bioavailability of NO (nitric oxide)	Decrease cardiac damage and hypertension	[97]
	Isoproterenol induced myocardial infarction in rats (10, 20, and 40 mg/kg)	Decreased lipid peroxidation and levels of ROS	Cardioprotective agent	[3]
	Doxorubicin-induced cardiotoxicity (10 mg/kg body weight)	The reduced serum concentration of AST, LDH, and CK-MB	Protected against cardiotoxicity	[61]
Naringenin	In vitro assay on H9c2 cardiomyocyte cells	Naringenin produced an inhibitory effect against daunorubicin apoptosis of H9c2 cardiomyocyte cells	Decreased inflammation ultimately increase cardiac function	[75]