Table 3.

Sex-stratified results of multivariable linear regression analyses (difference in scaled scores associated with a twofold increase in exposure and 95% CI) ¹ assessing the relation of prenatal exposure to a five-chemical mixture with Delis–Kaplan Executive Function System inhibition scaled scores among adolescents in the main analysis group ².

	Design Fluency Total Correct Scaled Score			Color–Word Interference Completion Time Scaled Score
Exposure	Males Difference (95% CI)	Females Difference (95% CI)	p 3	Males Difference (95% CI)	Females Difference (95% CI)	p 3
Log2 DDE	−0.18 (−0.70, 0.34)	−0.17 (−0.66, 0.32)	0.7	0.00 (−0.47, 0.47)	0.25 (−0.23, 0.72)	0.4
Log2 HCB	−0.19 (−0.64, 0.27)	0.34 (−0.12, 0.81)	0.1	−0.03 (−0.54, 0.48)	−0.11 (−0.59, 0.38)	0.8
Log2 ΣPCB4	0.04 (−0.45, 0.53)	−0.25 (−0.78, 0.28)	1.0	−0.09 (−0.60, 0.43)	−0.47 (−0.99, 0.04)	0.5
Log2 Pb	0.28 (−0.25, 0.81)	−0.25 (−0.63, 0.13)	0.4	0.20 (−0.39, 0.79)	−0.05 (−0.44, 0.33)	0.5
Log2 Mn	1.90 (0.47, 3.34) *	−0.06 (−1.47, 1.36)	0.1	−0.80 (−1.69, 0.09)	−0.48 (−1.34, 0.37)	0.5
Log2 Mn2	0.07 (−1.22, 1.36)	−0.27 (−1.67, 1.12)	0.3
Log2 DDE $\times$ Log2 Mn	0.83 (0.06, 1.60) *	0.10 (−0.64, 0.84)	0.2
Log2 DDE $\times$Log2 Mn2	0.49 (−0.37, 1.35)	0.03 (−0.74, 0.80)	0.3

¹ Exposures have been log2-transformed and models have been adjusted for all listed exposures, child race, sex, age at exam, year of birth, and HOME score; maternal marital status at child’s birth, IQ, seafood consumption during pregnancy, and smoking during pregnancy; maternal and paternal education and annual household income at child’s birth; study examiner. ² Main analysis group: complete inhibition outcome, covariate and exposure data for DDE, HCB, ΣPCB_4, Pb and Mn, total n = 373; males n= 179; females n = 194. ³ p-value for chemical-sex interaction term included in multivariable linear regression model. * p < 0.05. Abbreviations: DDE: dichlorodiphenyldichloroethylene; HCB: hexachlorobenzene; ΣPCB₄: Sum of 4 PCB congeners (118, 138, 153, 180); Pb: lead; Mn: manganese.