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. 2021 Nov 22;10(11):3260. doi: 10.3390/cells10113260

Figure 2.

Figure 2

Exposure of CF HBE to pediatric BALF enhances F508del CFTR rescue. (A) CFTR responses from F508del/F508del HBE cultures evaluated in Ussing chambers. Cultures were apically exposed to 30 µM BALF or SMM and serosally treated with vehicle or 5 µM VX-661. Data are expressed as mean ± SEM. ns = not significant; 2 donors, five to six cultures/experimental group. (B) Representative CFTR Western blot to analyze F508del maturation (upper band); (C) IL-8 secretion (pg/mL of culture media) from the F508del/F508del HBE evaluated in (A). * p < 0.05. Data are expressed as mean ± SEM. Modified from Gentzsch et al., 2021 [32].