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Theoretical and mathematical modeling of the event of urinary SARS-CoV-2 shedding. (a) Schematic diagram showed the renal inflow-infiltration-injury-into urine (“4I” model) to illustrate the course and outcome of SARS-CoV-2 infection in kidney. (b) Virus excretion can be simplified as a basic effector motif, consisting of input signal (inflow virus), effector (kidney) and output signal (urine shedding). (c) Function equation and curve of analytic mathematical model.
