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. 2021 Oct 27;11(11):1147. doi: 10.3390/life11111147

Figure 2.

Figure 2

PRMT1 regulates chromatin dynamics. PRMT1-dependent H4R3 methylation (R3me2a) allows the recruitment of the Tudor domain-containing protein, TDRD3, which in turn associates with topoisomerase IIIβ (Top IIIβ) to reduce R-loop formation and RNA polymerase II (RNA pol II) to promote transcriptional activity. Concomitantly, H4R3me2a-dependent activation of histone acetyltransferases p300 and pCAF induces acetylation of H4K5, H4K8, H4K12 but also of H3K9 and H3K14. H4K5 and H4K12 are involved in the recruitment of TAFII250 that associates with RNA pol II. H4K5ac and H4K16ac are also involved in PRMT1-activity regulation. Ac = Acetylation, m = methylation.