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. 2021 Oct 25;7(11):901. doi: 10.3390/jof7110901

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Late S. cerevisiae ergosterol biosynthetic pathway. Erg1: squalene monooxygenase. Erg7: lanosterol synthase. Erg11: lanosterol C-14 demethylase. Erg24: sterol C-14 reductase. Erg25: sterol C-4 methyloxydase. Erg26: sterol C-3 dehydrogenase. Erg27: sterol C-3 ketoreductase. Erg28 and Erg29: C-4 demethylation complex reaction. Erg6: sterol C-24 methyltransferase. Erg2: sterol C-8 isomerase. Erg3: sterol C-5 desaturase. Erg5: sterol C-22 desaturase. Erg4: sterol C-24 reductase. Sterol intermediates, enzymes, and their requirements of oxygen and iron are shown.