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Oncogenesis signaling of malignant melanoma and possible roles of omega-3 PUFAs. BRAF plays a role in MAPK pathway activation, which regulates the development of tumor cells, such as apoptosis, cell growth, and proliferation. NRAS mutations are related to the regulation of PI3K. Ultraviolet light exposure dysregulates p53 expression, leading to the suppression of tumor cell apoptosis.
