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Oncogenesis signaling of squamous cell carcinoma and possible roles of omega-3 PUFAs. P53 gene mutation is a crucial step in the development of cutaneous squamous cell carcinoma. P53 is responsible for cell apoptosis, DNA repair, and cell cycle arrest in squamous cell carcinoma. In addition, EGFR-mediated PI3K/AKT signaling and NRAS/RAF/MEK/ERK signaling also contribute to the development of squamous cell carcinoma.
