Table 1.

Summary of detailed action of omega-3 PUFAs against skin cancers.

Skin Cancers	Detailed Action
Melanoma	Reduce the risk of melanoma by DHA/EPA intake [27] Enhance the sensitivity to chemotherapy by EPA and DHA [28,29,30,31,46,47,48]. Suppress tumor growth by linoleic acid, EPA, DHA [32,37,41,42,44,45]. Suppress tumor metastasis by EPA [33,37] Suppress tumor invasion by EPA and DHA [34,37] Enhance ROS production and P53 induction by DHA and EPA [40]. Suppress debris-stimulated cancer progression by RvD1, RvD2, or RvE1 [50]
BCC	Reduce the risk of BCC by α-linolenic acid and linoleic [56].
ATLL	Synergistic effect on cell cycle arrest and cell death by the combination of DHA with chemotherapy [66].
DLBCL	Low intake of omega-3 fatty acids is associated with unfavorable survival [69].
SCC	Enhance the toxicity by DHA [75]. Reduce tumor size and cancer-derived cytokines/chemokines by RvD2 [76]. Suppress cell proliferation by EPA [77] Suppress tumor growth by the combination of Omega-3 PUFAs with ionizing radiation [78]. Suppress migration by EPA [81].