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. 2021 Nov 10;22(22):12163. doi: 10.3390/ijms222212163

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pristane-induced arthritis upregulates BMP-7 expression in the hippocampus/dentate gyrus in male rats. (A) Representative immunofluorescent pictures show staining with anti-BMP-7 antibody in paraffin-embedded sections of brain tissue obtained from male and female DA rats: control (treated with saline); PIA onset (between 9th and 12th day after induction); PIA peak (between 16th and 20th day after induction); PIA remission (between 20th and 25th day after induction). (B) BMP-7 immunoreactivity in the hippocampus/dentate gyrus. The immunofluorescent signal quantification was performed using Cell F v3.1 software analysis on 12 regions of interest (3 slides/rat × six animals/group). Values are expressed as mean grey value ± SD (N = 24). One-way ANOVA followed by the post hoc Scheffé test: *** p < 0.001. Insert shows staining in a slide incubated without primary anti-BMP7 antibody (negative control). Scale bars indicate 50 μm.