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. 2021 Nov 10;22(22):12163. doi: 10.3390/ijms222212163

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pristane-induced arthritis causes greater inflammation in synovial tissue in female than in male rats. (A) Representative photomicrographs show staining with H&E for measuring the level of inflammation (Krenn scoring system) and anti-CD3 antibody for detecting T cells in paraffin-embedded sections of the metatarsophalangeal joints obtained from male and female DA rats: control (treated with saline); PIA onset (between 9th and 12th day after induction); PIA peak (between 16th and 20th day after induction); PIA remission (between 20th and 25th day after induction). CD3 is expressed in synovial and T cells. (B) Krenn synovitis score of metatarsophalangeal joints. Synovitis was scored by two independent observers under light microscope (3 slides/rat × 6 rats/group). Values are expressed as mean value ± SD (N = 24). One-way ANOVA followed by the post hoc Scheffé test: ** p < 0.01 and *** p < 0.001. Insert shows staining in a section incubated without primary anti-CD3 antibody (negative control). Scale bars indicate 50 μm.