Table 1.
Baseline characteristics across galectin-3 quartiles at visit 5 of the ARIC Study.
| Visit 5 galectin-3 quartiles (ng/mL) | P trend | ||||
|---|---|---|---|---|---|
| Q1 (4.2–13.8) | Q2 (13.9–16.5) | Q3 (16.6–19.8) | Q4 (19.9–94.3) | ||
| cfPWV (cm/s) | 1128±293.2 | 1155±294.8 | 1177±301.0 | 1188±319.3 | <0.001 |
| Age (year) | 74.3±4.9 | 74.6±4.6 | 75.5±5.0 | 76.5±5.3 | <0.001 |
| Female % | 46.8 | 57.2 | 63.5 | 70.7 | <0.001 |
| Black % | 16.0 | 19.9 | 23.6 | 27.9 | <0.001 |
| SBP (mmHg) | 129.5±17.1 | 130.2±16.9 | 130.5±17.3 | 130.0±18.3 | 0.297 |
| DBP (mmHg) | 67.1±10.3 | 66.8±10.1 | 66.6±10.5 | 64.6±10.4 | <0.001 |
| Pulse pressure (mmHg) | 62.4±13.7 | 63.4±13.7 | 63.9±14.1 | 65.4±15.1 | <0.001 |
| Mean arterial pressure (mmHg) | 87.9±11.3 | 87.9±11.1 | 87.9±11.4 | 86.4±11.5 | 0.003 |
| Heart beat (beat/min) | 64.1±10.8 | 65.1±10.7 | 65.6±10.9 | 65.6±11.1 | 0.001 |
| Hypertensive medication % | 59.7 | 69.7 | 72.9 | 86.4 | <0.001 |
| Hypertension % | 62.6 | 70.4 | 72.8 | 83.7 | <0.001 |
| BMI (kg/m2) | 27.2±4.3 | 27.6±4.4 | 27.8±4.5 | 28.6±4.6 | <0.001 |
| Diabetes (%) | 26.1 | 23.1 | 30.5 | 36.3 | <0.001 |
| LDL-C (mg/dL) | 108.3±32.9 | 107.1±33.9 | 106.8±35.7 | 102.0±34.8 | <0.001 |
| Cholesterol lower medication (%) | 48.4 | 53.8 | 54.9 | 62.6 | <0.001 |
| Current smoking (%) | 6.0 | 5.0 | 6.1 | 5.6 | 0.982 |
| eGFR (mL/min/1.73m2) | 77.7±13.1 | 73.9±14.2 | 70.9±15.0 | 61.2±18.3 | <0.001 |
| Hs-CRP (mg/L) | 1.5 (0.8, 3.1) | 1.8 (0.9, 3.6) | 1.9 (0.9, 3.9) | 2.3 (1.1, 4.7) | <0.001 |
| Prevalent CHD (%) | 9.7 | 12.0 | 11.6 | 14.6 | 0.001 |
| Prevalent PAD (%) | 4.3 | 6.8 | 8.8 | 14.1 | <0.001 |
*
Data presented as mean±sd, median (25th, 75th percentile), or percentage; P trend were calculated by test of trend across ordered groups. Abbreviations: cfPWV = carotid-femoral pulse wave velocity, SBP = systolic blood pressure, DBP = diastolic blood pressure, BMI = body mass index, LDL-C = low-density lipoprotein cholesterol, eGFR = estimated glomerular filtration rate, CHD = coronary heart disease, hs-CRP = high-sensitivity C-reactive protein, PAD = peripheral artery disease