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. Author manuscript; available in PMC: 2021 Nov 26.
Published in final edited form as: Am J Physiol Heart Circ Physiol. 2003 May 22;285(3):H1040–H1047. doi: 10.1152/ajpheart.00981.2002

Fig. 2.

Fig. 2.

Responses to intracoronary adenosine (ADO) injections. A control and an experimental dose-response curve were obtained in each heart. Mean responses from 2 hearts are shown in each panel. Both P1 receptor blockade with 50 μM 8-(p-sulfophenyl) theophylline (8-SPT; A) and addition of 6 U/ml adenosine deaminase (ADA) to the perfusate (B) effectively antagonize adenosine responses and shift the dose-response curves severely rightward. Time-control experiments (C) demonstrate that the responses to adenosine are stable over time. Concentrations indicate the concentration in the 25-μl bolus injectate. The width of the horizontal bar on the experimental dose-response curve indicates the difference in rightward shift in the 2 hearts. *P < 0.01 vs. the adenosine time-control experiment.