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Definitions for a decision problem with two health states and two intervention options
| Intervention | Disease state | Costs | Risk criterion at threshold t | Outcome probability |
|---|---|---|---|---|
| Yes | Diseased | CTP | r > t | μ × sens(t) |
| No | Diseased | CFN | r ≤ t | μ × {1 − sens(t)} |
| Yes | Not Diseased | CFP | r > t | (1 − μ){1 − spec(t)} |
| No | Not Diseased | CTN | r ≤ t | (1 − μ)spec(t) |
Abbreviations: C, cost; r, risk; t, threshold; μ, probability of disease or adverse outcome; sens, sensitivity; spec, specificity.
