Effects of opioids on motor behaviour. Abbreviations: GABA, gamma-aminobutyric; cAMP, cyclic adenosine monophosphate; PKA, protein kinase A; CRE, cAMP-responsive element; CREB, cAMP-responsive element binding protein; D1, dopamine receptor-1; DARPP-32, dopamine- and cAMP-regulated phosphoprotein of 32 kDa; NMDA, N-methyl-D-aspartate receptor; PDEs, Cyclic nucleotide phosphodiesterases; NA, noradrenaline, VTA, ventral tegmental area; NAc, nucleus accumbens. Symbols: solid arrow, strong activation; dashed arrow, moderate activation; solid T-shaped line, strong inhibition; dashed T-shaped line, moderate inhibition, upward arrow, increased effect; downward arrow, decreased effect. The figure was made with www.biorender.com (accessed on 19 October 2021).