Figure 3.

PPI network analysis. The PPI network for the 175 core set genes containing 187 nodes and 2668 interactions was constructed using the STRING website and visualized by Cytoscape (version: 3.8.2,) by mapping the “degree parameter” to node size. As the node size increased, the value of the connectivity degree of node genes increased. Proteins with a degree connectivity of >50 represent the most significant nodes in the PPI network and are colored from orange to red based on their node degree. Cebpb is the most interconnected node (hub) in the network and is colored in yellow. Differently colored “edges” indicate the type of evidence supporting each interaction: dark purple, co-expression; light purple, physical interaction; light blue, co-localization; light green, shared protein domain; orange, predicted; grey, other.