Figure 7.

Time-course TF-gene regulatory networks revealed a common early and transient peak of transcription of upstream regulators modulating the expression of core set genes. Networks were visualized by Cytoscape. For each time-point, the node color is consistent with the logFC of each gene: genes in blue are downregulated by GF treatment, whereas the genes in red are upregulated. Targets are represented as circle nodes with purple borders and TF as green hexagon nodes. Regulons for each TF are represented by different edge colors. Target genes are grouped according to their biological functions.