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. 2021 Oct 29;13(11):1809. doi: 10.3390/pharmaceutics13111809

Figure 5.

Figure 5

Effects of pre-exposure to C-dots (500 µg/mL) hydrothermally derived from B. breve ATCC 15700 (B-C-dots) and E. coli ATCC 25922 (E-C-dots) on antibiotic killing in 24 h and 72 h grown E. coli biofilm. Exposure to 10 mM phosphate buffer (pH 7.4) was applied as a control. (a) Effects of 24 h ciprofloxacin treatment at different concentrations (indicated in multiples of its MBC, see Table S1) on the number of CFUs in E. coli ATCC 25922 biofilms. (b) Same as panel (a), now for 72 h ciprofloxacin treatment. All data are expressed as means ± standard deviations over triplicate experiments with separately prepared C-dots and different E. coli cultures. * p < 0.05, *** p < 0.001 and **** p < 0.0001 indicate significant differences with respect to pre-exposure to buffer or different C-dot suspensions (one way ANOVA).