. 2021 Nov 5;13(11):1869. doi: 10.3390/pharmaceutics13111869

Table 5.

Drug pharmacokinetic parameters after the administration of the optimized OFDF (F1) compared to the market tablet.

Pharmacokinetics Parameter	Treatment (Mean ± SD)
Pharmacokinetics Parameter	Optimized OFDF (F1)	Market Tablet
C_max (ng/mL) ^a	11.18 ± 7.86	6.44 ± 3.77
AUC_0–48 (ng.h/mL) ^a	108.92 ± 81.31	69.79 ± 52.92
AUC_0-∞ (ng.h/mL) ^a	165.07 ± 135.10	92.51 ± 67.35
t_max (h) ^a	0.94 ± 0.54	3.08 ± 1.88
t_1/2 (h) ^a	22.54 ± 4.11	22.32 ± 4.81
K (l/h) ^a	0.030 ± 0.01	0.030 ± 0.01
MRT ^a	37.90 ± 7.29	34.06 ± 8.24
% Relative bioavailability (%RB)	178.43	-

^a Data are the mean values (n = 6) ± SD.