Table 2.

Selected molecular functions altered in HF-MSS, based on Gene Ontology enrichment analysis.

Term ID 1	Term Description 2	Observed Gene Count 3	Background Gene Count 4	False Discovery Rate 5
GO:0003723	RNA binding	86	850	2.57 × 10−17
GO:0003729	mRNA binding	36	198	2.76 × 10−13
GO:0003727	single-stranded RNA binding	13	80	0.00011
GO:0003725	double-stranded RNA binding	11	70	0.00058
GO:0019843	rRNA binding	10	60	0.00079
GO:0008135	translation factor activity, RNA binding	11	84	0.0021
GO:0000049	tRNA binding	8	56	0.0079
GO:0061980	regulatory RNA binding	5	34	0.0424
GO:0016491	oxidoreductase activity	75	716	8.70 × 10−16
GO:0016860	intramolecular oxidoreductase activity	12	47	5.01 × 10−6
GO:0000166	nucleotide binding	134	2097	2.45 × 10−12
GO:0017076	purine nucleotide binding	108	1865	1.36 × 10−7
GO:0030554	adenyl nucleotide binding	79	1524	0.00039
GO:0008092	cytoskeletal protein binding	71	882	4.82 × 10−10
GO:0046961	proton-transporting ATPase activity, rotational mechanism	9	21	4.97 × 10−6
GO:0008553	proton-exporting ATPase activity, phosphorylative mechanism	9	23	8.55 × 10−6
GO:0015078	proton transmembrane transporter activity	12	120	0.0082
GO:0005178	integrin binding	19	122	2.30 × 10−6
GO:0050839	cell adhesion molecule binding	24	200	3.68 × 10−6
GO:0098634	cell-matrix adhesion mediator activity	3	7	0.0229

¹ Unique seven-digit identifier prefixed by GO. ² Textual description of the term. ³ Number of genes linked to that GO term in the input list. ⁴ Number of genes linked to a GO term in the entire background set. ⁵ Expected ratio of the number of false positive classifications (false discoveries) to the total number of positive classifications.