Table 3.

Cox proportional hazards regression for long-term mortality

Characteristics	Univariable Univariable		Multivariable
	HR (95% CI)	p value	HR (95% CI)	p value
Age, per 1 year increment	1.017 (1.014–1.019)	< 0.001	1.008 (1.005–1.010)	< 0.001
Male gender	1.136 (1.046–1.235)	0.003	1.201 (1.104–1.308)	< 0.001
Body mass index, per 1 decrement	1.025 (1.016–1.034)	< 0.001	1.035 (1.026–1.045)	< 0.001
Charlson comorbidity index, per 1 increment	1.192 (1.166–1.219)	< 0.001	1.120 (1.093–1.148)	< 0.001
APACHE II, per 1 increment	1.095 (1.089–1.102)	< 0.001	1.053 (1.046–1.061)	< 0.001
Receiving mechanical ventilation	2.093 (1.887–2.322)	< 0.001	1.068 (0.953–1.198)	0.256
Fluid overload, day 1–3, per 1 L increment	1.096 (1.085–1.106)	< 0.001	1.050 (1.039–1.061)	< 0.001
Receiving renal replacement therapy	2.309 (2.097–2.543)	< 0.001	1.469 (1.324–1.631)	< 0.001
Presence of shock	2.565 (2.366–2.780)	< 0.001	1.521 (1.387–1.667)	< 0.001
Immunocompromised patients	2.418 (2.200–2.658)	< 0.001	2.341 (2.123–2.581)	< 0.001
Positive culture of MDRO1	1.774 (1.635–1.925)	< 0.001	1.008 (1.005–1.010`)	< 0.001
Culture site
Blood	2.141 (1.938–2.364)	< 0.001	1.233 (1.104–1.378)	< 0.001
Respiratory tract	1.873 (1.731–2.028)	< 0.001	1.217 (1.109–1.337)	< 0.001
Urinary tract	1.648 (1.504–1.807)	< 0.001	1.230 (1.109–1.364)	< 0.001
Skin and soft tissue	1.519 (1.198–1.927)	0.001	0.943 (0.741–1.200)	0.633
Abdomen	1.835 (1.516–2.223)	< 0.001	1.028 (0.846–1.249)	0.780

¹MDRO, included methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococci, and carbapenem-resistant Gram-negative bacilli. HR hazard ratio, CI confidence interval, APACHE acute physiology and chronic health evaluation, MDRO multidrug-resistant organism