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. 2021 Oct 27;19(11):610. doi: 10.3390/md19110610

Table 1.

The chemical structures of phenazine-5,10-dioxide derivatives 159–166 and survival rate (%) in normoxia and hypoxia.

Structure/Name SF a,b,c
Norm Hypox
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159 R = NH2, Z 160 R = OH, Z		 (159): 100 ± 10
(160): 100 ± 7		 (159): 45 ± 4
(160): 75 ± 2
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161 		Nd. Nd.
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162 R = NO2, 163 R = Cl, 164 R = SCH3 		(162): 89 ± 10
(163): 100 ± 6
(164): 100 ± 6		 (162): 58 ± 4
(163): 44 ± 5
(164): 55 ± 3
Inline graphic
165 		(165): 57 ± 7 (165): 66 ± 6
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166 		(166): 100 ± 8 (166): 73 ± 4

a SF norm = survival fraction in normoxia at 20 mM on V79 cells. b SF hypox = survival fraction in hypoxia at 20 mM on V79 cells. c Values are means of two different experiments. The assays were done by duplicate and using at least three repetitions. Nd = not determined.