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. 2021 Nov 16;10(11):3189. doi: 10.3390/cells10113189

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Schematic of transplantation of hbNSPCs and hscNSPCs into the aligned collagen scaffold, Scale bars: 200 μm. (B) Immunofluorescence images of hbNSPCs and hscNSPCs, Scale bars: 100 μm. (C) Transplantation of the scaffold in an animal model. (D) Survival images of transplanted cells (hbNSPCs and hscNSPCs) after 1, 4, and 8 weeks. The images clearly show that hbNSPCs cells are not alive after 4 weeks (green dye) (the red dye responded to astrocytes), Scale bars: 250 μm. (E) Effect of two types of stem cells on suppression of inflammatory agents. hscNSPCs showed a better anti-inflammatory effect than that of hbNSPCs, Scale bars: 250 μm. Reprinted from [2] with permission from the Royal Society of Chemistry.