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. 2021 Oct 28;13(11):1803. doi: 10.3390/pharmaceutics13111803

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic illustration of the design and 3D hydrogel morphology composed of cellulose, NSs, and DOX for bimodal CTX/PTT-based cancer treatment. (a) Four kinds of gels: (a1) cellulose hydrogel, (a2) NSs-integrated matrix, (a3) DOX-loaded matrix, and (a4) NSs/DOX-containing hydrogel; (a5) DOX-CTX; (a6) NSs-based PTT; and (a7) bimodal CTX/PTT therapies. (b1–4) Graphical representation of in vivo CTX/PTT therapy using cellulose hydrogel matrix; (c) tumor size representative for each group. (Adapted with permission from Reference [24], ACS Applied Materials & Interfaces, published by American Chemical Society, 2018).