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Schematic illustration showing (a) the multi-step synthesis of NSs with polymer (PDA-PEG) modification along with Mn and DOX loading to treat ADR cancer treatment, (b) pH-based DOX release profiles from the designed complex, (c) drug release under the external stimuli of NIR irradiation, and (d) tumor photographs after extraction from various treated groups (adapted with permission from Reference [33], Chemical Engineering Journal, published by Elsevier, 2019).
