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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Ageing Res Rev. 2021 Nov 9;72:101510. doi: 10.1016/j.arr.2021.101510

Fig. 5. Iron metabolism and lifespan regulation in C. elegans.

Fig. 5.

A, excessive iron accumulation suppresses longevity in C. elegans, where ROS accumulation, ferroptosis, and cellular senescence may act as contributing factors. B, ISCU-1/ISCU, a central mitochondrial protein required for de novo biosynthesis of iron sulfur clusters, is essential for normal development during larval stages but accelerates aging during adulthood. C, suppressing the functions of ISCU-1 by iscu-1 RNAi extends lifespan and promotes stress resistance.