Figure 1.

Schematic model of diabetes-relevant mechanisms of β-cell death. Several mechanisms of β-cell death discussed in this review, including autoimmune-associated, islet amyloid-induced, proinflammatory cytokine-mediated, and ER stress- and oxidative stress-induced β-cell death are illustrated in this diagram. This model represents an integrated, but simplified and incomplete graphical representation of diabetes-associated mechanisms of β-cell death.