Figure 4.

The effect of M1 macrophages polarized by SFV-derived IFNg on 4T1(Luc2) tumor growth. The 4T1(Luc2) cells (1 × 10⁴) were orthotopically coinjected with 2 × 10⁴ M0 (4T1(Luc2)+M0) or M1 (4T1(Luc2)+M1) macrophages in BALB/c mice (n = 5 per group) at day 0. (a) In vivo bioluminescent imaging of 4T1(Luc2) tumors expressing luciferase (days 5–11). (b) Quantitative analysis of tumor bioluminescence and the tumor weights. (c) Bioluminescence imaging of lungs isolated from the tumor-bearing mice. Bars represent the means ± SD (n = 5); *—significant difference (p < 0.05); ns—nonsignificant.